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The use of glass ChemReactors

The BÜCHI high performance ChemReactor is a multipurpose pilot reactor system for chemical process development, scale-up, process simulation and kilo scale cGMP production in batch and semi-batch operation.

The system consists of:

Reactor with solid jacketed glass lined steel bottom stands for solid construction, excellent heat transfer, stable process conditions and temperatures, and a glass section to easily improve and control chemical reactions by visual observation.

Distillation glass overhead built with buchiflex components (unique flexible ball – socket joints) for multiple, reliable processes under full vacuum.

With a large number of options, standard- and custom-made components, we can build solutions to fulfil any requirement. The use of the unique ball/socket joints “büchiflex”, allow for easy retrofitting for new processes and maintenance.

Advantages of our ChemReactors

  • Unique flexible ball-socket joints (büchiflex)
  • No compensators required!
  • FDA conform made of borosilicate glass 3.3/ PTFE/ PFA
  • Reactor lift
  • Many options including distillation overhead, sampling system, reflux, probes, etc.
  • Corrosion resistant
  • Complies with ATEX zone I / CE / cGMP / CIP
  • Reliability of the equipment
  • Short downtimes
  • Economic daily operational costs
  • High productivity and reproducibility of high purity chemicals

Technical data for our ChemReactors

Volume 15 litre up to 250 litre
Pressure -1.0 (FV) up to +0.5 bar
Temperature -90°C to +200°C
Materials Borosilicate glass 3.3 / glass-lined steel / PTFE / PFA / Tantalum
Certification ATEX zone I / CE / cGMP / FDA

Our specialists are here to advise on the optimal solution for your process. Our engineers will design a reactor system for you according your specifications.

Let's talk!

Examples of application areas for ChemReactors

  • API synthesis
  • Vacuum distillation
  • Azeotropic distillation (phase separation)
  • Evaporation to any desired consistency
  • Multi-component reactions
  • Gas introduction into liquid phase
  • Chemical synthesis
  • Extraction of multi-phase mixture
  • Crystallization
  • Refluxing
  • Multiple chemical reactions liquid/liquid, liquid/solid
  • Low temperature chemistry
Glass reactor systems_glass-lined reactor

Glass-lined reactor vessel

Glass reactor systems_agitator

ATEX stirrer drive

Glass reactor systems_Lifting / lowering device (optional)

Lifting / lowering device (optional)

Glass reactor systems_cryogenic reactor vessel

160 litre cryogenic reactor vessel

Glass reactor systems_High containment powder dosing

High containment powder dosing